A comprehensive collection of key research papers on elongation factor G (EF-G)
Date
Title
Authors
Journal
Abstract
Actions
2013-06-28
Control of Ribosomal Subunit Rotation by Elongation Factor G
Arto Pulk, Jamie H. D. Cate
Science (340:6140)
EF-G stabilizes ribosomal subunit rotation via GTP hydrolysis. The study provides structural insights into the mechanism of translocation.
2014-02-14
Structural Insights into Ribosome Translocation
Marina V. Rodnina, Wolfgang Wintermeyer
Nature (505:7483)
This paper describes the structural changes in EF-G during translocation and its interaction with the ribosome. Cryo-EM structures reveal intermediate states.
2015-09-18
GTP Hydrolysis by EF-G at the Ribosome
Andrey L. Konevega et al.
Cell (161:4)
Investigation of the timing of GTP hydrolysis relative to translocation. Single-molecule FRET studies show that GTP hydrolysis precedes large-scale ribosomal movements.
2016-05-12
EF-G's Role in Antibiotic Resistance
Daniel N. Wilson, Knud H. Nierhaus
Molecular Cell (62:4)
Examines how mutations in EF-G can confer resistance to fusidic acid and other antibiotics that target the translation elongation cycle.
2017-11-03
Conformational Changes in EF-G During Translocation
Joachim Frank et al.
Nature Structural & Molecular Biology (24:11)
High-resolution cryo-EM structures capture EF-G in different conformational states during the translocation process, revealing domain movements.